Fig. 2: Structure of MLL4PHD2/3 in complex with ASXL2. | Nature Communications

Fig. 2: Structure of MLL4PHD2/3 in complex with ASXL2.

From: ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers

Fig. 2

A ribbon diagram (a) and a surface representation (b) of the solution NMR structure of the PHD2 (yellow) and PHD3 (wheat) fingers of MLL4 in complex with ASXL2 (blue). Zinc ions (gray spheres) coordinating cysteine and histidine residues are shown as stick and labeled. c Electrostatic surface potential of the MLL4PHD2/3:ASXL2 complex colored blue and red for positive and negative charges, respectively. d The MLL4PHD2/3 and ASXL2 residues involved in the complex formation are shown in sticks and labeled.

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