Fig. 2: Three spatiotemporal trajectories of LB pathology. | Nature Communications

Fig. 2: Three spatiotemporal trajectories of LB pathology.

From: Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Fig. 2

SuStaIn-inferred disease progression patterns of regional Lewy-type α-synuclein pathology. Three distinct trajectories were identified and termed (A) “S1: OBT-early/Limbic-early”, (B) “S2: OBT-early/Brainstem-early”, and (C) “S3: Brainstem-early/OBT-later”. Brain maps of α-synuclein deposition are shown for SuStaIn stage 1, 6, 11, 21, and 31, with colors indicating severity of pathology (red = mild, purple = moderate, blue = severe, black = very severe). Below, positional variance diagrams are shown. Each box represents the certainty that a brain region has reached a certain level of pathology (mild, moderate, severe, and very severe) at a given SuStaIn (i.e., disease progression) stage, with darker colors representing more confidence. Brain schematics were generated using: https://github.com/AllenInstitute/hba_brain_schematic (Copyright © 2023. Allen Institute. All rights reserved.). Amyg amygdala, Cing anterior cingulate, EC entorhinal cortex, Med medulla, SN substantia nigra, SuStaIn Subtype and Stage Inference.

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