Fig. 2: ArboScan profiles of Zika infected individuals.
From: Precision arbovirus serology with a pan-arbovirus peptidome
a Acute and convalescent serum was collected from individuals who tested positive for Zika RNA. VARscores from flaviviruses were compared between individuals who had pre-existing flavivirus IgG (prior dengue) and those who did not (no prior dengue) at acute and convalescent time points (No prior dengue, Acute n = 8; Prior dengue, Acute n = 19; No prior dengue, Convalescent n = 8; Prior dengue, Convalescent n = 19). Boxes indicate median and interquartile range of each group. b Zika VARscore were compared to Zika plaque reduction neutralizing titer (PRNT) (Spearman correlation, rho = 0.61, p = 2.4 × 10-6) and dengue VARscores were compared to corresponding dengue PRNT (Spearman correlation, rho = 0.49, p = 2.9 × 10-8). c Prevalence of antibody reactivity to Zika epitopes was evaluated for each sample group. Zika infected individuals with or without pre-existing flavivirus antibodies generated antibodies to Zika non-structural protein (NS) 2a, NS2b, membrane glycoprotein precursor (Pr), capsid (C), and envelope (E). Source data are provided as a Source Data file.
