Fig. 5: Antibacterial properties of analogue 2. | Nature Communications

Fig. 5: Antibacterial properties of analogue 2.

From: Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target

Fig. 5: Antibacterial properties of analogue 2.

Time-killing curve against S. aureus ATCC 29213 (a) and E. coli ATCC 25922 (b) not treated (black circle) or treated with MIC×1/4 (blue diamond), MIC×1 (orange triangle), and MIC×4 (grey square). These data were collected from three independent experiment (n = 3). Error bars represents SD. c Resistance emergency plot against S. aureus ATCC 29213 treated with MIC×1/2 drugs (rifampicin 0.004 μg/mL (black triangle), vancomycin 0.5 μg/mL (orange circle), or compound 2 0.5 μg/mL (blue diamond)). d The efficacy of analogues against S. aureus (ATCC 29213) mouse thigh infection model. The dots represent the raw data, bar graph indicates average values (n = 4,5 biologically independent mice). Error bars represents SD. Dose (mg/kg) was shown in parenthesis after the compounds’ name or numbers.

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