Fig. 4: Mutational propensities of the analysed fibril proteins.
From: Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis
a Length of the disordered segments (d.s.) and core segments (c.s.) of the presently analysed IGLV3-19-derived AL amyloid fibrils (left, n = 3, biological replicates) and of two other fibril structures (right, n = 2, biological replicates): FOR001 (IGLV1-51)16 and FOR006 (IGLV1-44)14. b Number of the mutations in the two types of segments for the fibrils described in (a). c Mutational frequencies of these fibrils. d Mutational propensities of these fibrils. The colour coding is consistent in all panels. Grey data points: individual values of the IGLV3-19-derived AL amyloid fibrils. Bars, error bars: average values of these fibrils and standard deviation. Significant differences between the core and disordered segments are indicated by asterisks: p-value of 0.1 (*) and p-value of 0.01 (**). Non-significant (ns). Statistical analysis was performed using a two-sided t test. Source data are provided as a Source Data file.
