Fig. 3: TIMPKs assembly order pattern. | Nature Communications

Fig. 3: TIMPKs assembly order pattern.

From: Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS

Fig. 3

Many of the TIMPKs (Type 1 Modular Polyketides) are non-colinear, i.e., the order of assembly of substrates is not the same as the linear order of the modules on the PK genes. For non-colinear T1MPKs, we can identify the true order of substrates by identifying docking domains at the beginning (head) and end (tail) of modules that interact with each other. In the graph, the head and tail that are in the same color represent cognate docking domains.

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