Fig. 1: Schematic illustrations of the construction of bacterial targeted antibiotic nanodelivery systems.
From: Guiding antibiotics towards their target using bacteriophage proteins
a Heterologous expression of targeting proteins by employing bacteriophage origin RBPs and CBDs. b Development of two distinct nanodelivery systems by employing heterologous expressed RBP and CBD as targeting devices: lipid-coated UPSNs (LUN) bearing RBPs (LUN@RBP) and CBDs modified UPSNs (UPSN@CBD). c In a CRKP-induced mouse pneumonia model, antibiotic-loaded LUN@RBP (Ant@LUN@RBP) more effectively suppressed CRKP infections than untargeted antibiotic nanoparticles or of free antibiotics. d In an MRSA-induced mouse pneumonia model, antibiotic-loaded UPSN@CBD (Ant@UPSN@CBD) more effectively suppressed MRSA infections than untargeted antibiotic nanoparticles and free antibiotics.
