Fig. 5: Derivatization of the C-I bond of β-iodo vinylphosphine oxides 3. | Nature Communications

Fig. 5: Derivatization of the C-I bond of β-iodo vinylphosphine oxides 3.

From: Regio- and stereoselective access to highly substituted vinylphosphine oxides via metal-free electrophilic phosphonoiodination of alkynes

Fig. 5

Reaction conditions: (a) NaN3, DMAC; (b) CuCN, DMF; (c) pyrrole, CuI, DMEDA, K3PO4, toluene; (d) Zn, H2O/AcOH; (e) 4-methylphenylboronic acid, Pd2(dba)3, X-Phos, Cs2CO3, DMF/H2O; (f) tributyl(ethenyl)stannane, Pd(PPh3)2Cl2, DMF; (g) methyl acrylate, Pd(OAc)2, TBAB, NaHCO3, DMF.

Back to article page