Fig. 8: In-liquid biointerfacing.
From: Unravelling the operation of organic artificial neurons for neuromorphic bioelectronics
a OAN circuit including the cellular barrier between the apical electrolyte (point A) and the basal electrolyte (point B). The model of the cellular barrier includes the gate \({R}_{{{{{{\rm{G}}}}}}}\) resistance, the apical electrolyte equivalent resistance \({R}_{{{{{{\rm{Ea}}}}}}}\), and the basal electrolyte equivalent resistance \({R}_{{{{{{\rm{Eb}}}}}}}\), the ion resistance \({R}_{{{{{{\rm{M}}}}}}}\) and capacitance \({C}_{{{{{{\rm{M}}}}}}}\) of the membrane, and the channel resistance \({R}_{{{{{{\rm{C}}}}}}}\). b Measurements of the OAN without cellular barrier (blue line), with intact cellular barrier interfaced with the OAN (green line), and with disrupted cellular barrier (purple line). Insertion and disruption of the cellular barrier is highlighted with the vertical dashed lines. c Transient numerical simulations of the OAN without cellular barrier (blue line), with intact cellular barrier interfaced with the OAN (green line), and with disrupted cellular barrier (purple line). Insertion and disruption of the cellular barrier is highlighted with the vertical dashed lines. d Model of the OAN and cellular barrier accounting for an input signal at the apical electrolyte (point A) and output signal at the basal electrolyte (point B). e Calculated transfer function module between A-B \(\left|{H}_{{{{{{\rm{AB}}}}}}}\right|\) for the frequency range 1 Hz–105 Hz. The signal is attenuated in a frequency range relevant to the oscillation (range 10–150 Hz). f Impact of the membrane resistance on the OAN oscillations. g Impact of the membrane capacitance on the OAN oscillations. h Time constant of the oscillation decay \(({\tau })\) after the cellular barrier insertion as a function of RM.
