Fig. 2: Highly preserved local structure during different types of visual stimuli.
From: Stimulus type shapes the topology of cellular functional networks in mouse visual cortex
A Illustration of the surrogate models: Erdős–Rényi model, Degree-preserving model, Pair-preserving model and Signed-pair-preserving model that exhibit a progressive increase in the number of preserved network properties. The preserved properties are the number of nodes (V)/edges (E), degree distribution, neuron-pair distribution and signed-pair distribution, respectively. The real network used to generate the synthetic networks is sampled from an example session during drifting gratings. B Relative count of signed neuron pairs using Erdős–Rényi model. All three types of bidirectional pairs are considerably over-represented. Box plots indicate median (middle line), 25th, 75th percentile (box) and minimum and maximum (whiskers), n = 7 mice. C 13 types of motifs without edge signs. Examples of signed motifs based on Feedforward Loop structure (motif ID = 6) are shown. Positive-FFL-based (pFFLb) motifs are defined as motifs with at least one FFL structure consisting of all positive connections. Note that pFFLb motifs can be classified into four types based on the number of mutual connections: zero (ID = 6), one (ID = 9, 10, 11), two (ID = 12) and three (ID = 13). In what follows, we use the prefix “p” or “n” to denote signed motif types with only positive connections or only negative connections, respectively. D Motif intensity significance sequences of all signed motifs (signed three-neuron subnetworks). Each row shows results for a certain stimulus type and each color corresponds to a certain unsigned motif structure. Motif intensity significance for each signed motif is obtained through its intensity Z-score of the empirical network with Signed-pair-preserving model as the reference. The overall sequences are highly similar across visual stimulus classes, with six types of over-represented motifs (pFFLb motifs) and three under-represented motifs preserved. It is worth noting that the above-mentioned nine significant motifs only contain positive connections.
