Fig. 4: Dexamethasone has discordant effects on cell type specific gene expression in lung and peripheral blood that are reproducible in external datasets.
From: Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19
Net enrichment scores from gene set enrichment analysis in blood (a) and lung (b), faceted by cell type. Orange circles have a positive net enrichment score (NES), indicating the pathway is more highly expressed in dexamethasone-treated COVID-19 patients (Dex) or healthy controls relative to NoDex subjects. Solid circles identify pathways where GSEA BH-adjusted p < 0.1, empty circles identify pathways with GSEA BH-adjusted p ≥ 0.1, and blank spaces indicate no GSEA NES score was calculated for that pathway. Significance was determined using a one-sided test based on a modified Kolmogorov–Smirnov statistic. Datasets represented are from COMET (whole blood, TA), Sinha et al. (blood) and Liao et al. (BAL). Ns reported in Fig. S8 and Supplementary Data File 2.
