Fig. 4: IRF4-dependent dendritic cells (cDC2) participate to the homeostasis of RORγt+ pTregs and Th17 cells. | Nature Communications

Fig. 4: IRF4-dependent dendritic cells (cDC2) participate to the homeostasis of RORγt+ pTregs and Th17 cells.

From: Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells

Fig. 4

A Flow cytometry analysis of Th17 cells in the small intestine (n = 9 mice per group), colon (n = 9 mice per group) and mesenteric lymph nodes (mesLNs) (n = 7 mice per group) of mice lacking Irf4 in dendritic cells (Irf4ΔDC) and Irf4flox/flox controls (ctrl). B Flow cytometry plots and analysis of RORγt+ pTregs in the small intestine (n = 9 mice per group), colon (n = 9 mice per group) and mesenteric lymph nodes (mesLNs) (n = 7 mice per group) of mice lacking Irf4 in dendritic cells (Irf4ΔDC) and Irf4flox/flox controls (Ctrl). C, D Flow cytometry analysis of CCR9 or ITGβ7-expressing RORγt+ pTregs (C) and Th17 cells (D) in the mesenteric lymph nodes of mice lacking Irf4 in dendritic cells (Irf4ΔDC) and Irf4flox/flox controls (Ctrl) (n = 7 mice per group). All data in this figure are presented as mean values ± SEM. Statistical significance has been assessed with a two-sided T test and stars display P value. All panels correspond to two independent experimental groups.

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