Table 1 Characteristics of cohort at baseline
From: Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals
Characteristics | Overall | Cognitively unimpaired | Cognitively impaired | ||||||
|---|---|---|---|---|---|---|---|---|---|
Black N = 324a | White N = 1547 | p | Black N = 234 | White N = 1027 | p | Black N = 89 | White N = 520 | p | |
Sample characteristics | |||||||||
Site (n for WU/UPenn/UAB) | 249/63/12 | 1412/115/20 | <0.0001 | 181/47/6 | 934/83/10 | <0.0001 | 67/16/6 | 478/32/10 | <0.0001 |
Number of plasma samples per individual (n with 1/2/3/ ≥ 4 samples) | 166/74/53/31 | 788/340/207/212 | 0.15 | 98/58/50/28 | 392/258/181/196 | 0.056 | 68/16/3/2 | 396/82/26/16 | 0.84 |
Years between the 1st and last plasma sample (mean, SD)b | 5.11 (3.52) | 6.93 (4.17) | <0.0001 | 5.22 (3.54) | 7.17 (4.22) | <0.0001 | 4.01 (2.94) | 5.70 (3.67) | 0.018 |
Fasting status (n for fasting/non-fasting, % fasting) | 117/207 (36.1%) | 1015/532 (65.6%) | <0.0001 | 91/143 (38.9%) | 734/293 (71.5%) | <0.0001 | 25/64 (28.1%) | 281/239 (54.0%) | <0.0001 |
Demographics | |||||||||
Baseline age (mean, SD) | 70.2 (8.6) | 70.5 (9.5) | 0.26 | 69.0 (7.78) | 68.3 (9.67) | 0.42 | 73.8 (9.41) | 74.8 (7.55) | 0.40 |
Sex (n, % female) | 234 (72.2%) | 827 (53.5%) | <0.0001 | 172 (73.5%) | 595 (57.9%) | <0.0001 | 61 (68.5%) | 232 (44.6%) | <0.0001 |
Years of education (mean, SD) | 15.3 (2.92) | 15.8 (2.81) | 0.002 | 15.4 (2.84) | 16.3 (2.55) | 0.0001 | 14.8 (3.07) | 14.9 (3.06) | 0.71 |
APOE ε4 status (n for carrier/non-carrier/missing, % carrier) | 146/172/6 (45.1%) | 659/878/10 (42.6%) | 0.35 | 96/136/2 (41.0%) | 359/667/1 (35.0%) | 0.08 | 50/35/4 (56.2%) | 300/211/9 (57.7%) | 1.00 |
Medical conditions | |||||||||
BMI status (n for overweight or obese/underweight or normal/missing, % overweight or obese) | 225/52/47 (69.4%) | 805/426/316 (52.0%) | <0.0001 | 179/30/25 (76.5%) | 569/282/176 (55.4%) | <0.0001 | 46/22/21 (51.7%) | 236/144/140 (45.4%) | 0.46 |
Hypertension status (n for positive/negative/missing, % positive) | 212/108/4 (65.4%) | 655/878/14 (42.3%) | <0.0001 | 154/79/1 (65.8%) | 402/618/7 (39.1%) | <0.0001 | 58/29/2 (65.2%) | 253/260/7 (48.7%) | 0.004 |
Diabetes status (n for positive/negative/missing, % positive) | 56/223/45 (17.3%) | 93/1150/304 (6.0%) | <0.0001 | 44/167/23 (18.8%) | 53/805/169 (5.2%) | <0.0001 | 12/56/21 (13.5%) | 40/345/135 (7.7%) | 0.13 |
Stroke status (n for positive/negative/missing, % positive) | 6/258/60 (1.9%) | 25/1401/121 (1.6%) | 0.74 | 3/188/43 (1.3%) | 14/945/68 (1.4%) | 1.00 | 3/70/16 (3.4%) | 11/456/53 (2.1%) | 0.63 |
