Fig. 1: Background and our strategy. | Nature Communications

Fig. 1: Background and our strategy.

From: Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions

Fig. 1

a Previous arts on transition-metal-catalyzed 1,2-difunctionalization of alkynes (three-component reaction, well-studied). b Our design (four-component reaction, unknown). c Synthesis of polysubstituted 1,3-dienes via nickel-catalyzed four-component reaction with two alkynes (this work). 3-component = three-component reaction, ATRA = atom transfer radical addition reaction, RA = radical addition reaction, AI = alkyne insertion reaction.

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