Fig. 1: Schematic diagram of the prediction stage of MTWAS. | Nature Communications

Fig. 1: Schematic diagram of the prediction stage of MTWAS.

From: Partitioning and aggregating cross-tissue and tissue-specific genetic effects to identify gene-trait associations

Fig. 1: Schematic diagram of the prediction stage of MTWAS.

The prediction stage of MTWAS is divided into three steps. Step 1 does the expression imputation, where the missing entries of an observed expression matrix are imputed using information from other relevant tissues with the algorithm MissForest. Step 2 identifies cross-tissue eQTLs; and Step 3 detects tissue-specific eQTLs, and estimates effect sizes.

Back to article page