Table 5 Reactions for the oxidation of thioethers to sulfones

From: Liquid-liquid reactions performed by cellular reactors

Entry

Time 1

Conversion rate 1a

Time 2

Conversion rate 2b

13b

70 min

~100%

-

-

14

24 h

24.3%

48 h

99.9%

15

30 min

71.3%

4 h

~100%

16

30 min

30.0%

6 h

~100%

17c

24 h

23.5%

36 h

~100%

  1. aThe substrate concentration was analyzed using GC-MS, and at 30 min, it was found to be below the detection limit, indicating complete transformation. Reaction 17 was analyzed by UPLC-MS. Please refer to Supplementary Figs. 2533 for the GC-MS and NMR spectra of entries 13–17. 13 b: The oxidation product is sulphoxide, 17 c The oxidation product is sulphoxide.