Table 1 Characterization of the population used in the case study

From: Temporal stratification of amyotrophic lateral sclerosis patients using disease progression patterns

 

PRO-ACT

Lisbon ALS

p-value

 

n = 3880

n = 983

 

Sex

  

4.0 × 10−6

 Male

2460, 63.4%

545, 55.4%

–

 Female

1420, 36.6%

438, 44.6%

–

Age at onset (years)

  

0

 Median, IQR

57, 49–64

62, 54–71

–

 Average, Std

56.20, 11.33

61.44, 12.39

–

Diagnostic delay (months)

  

2.8 × 10−9

 Median, IQR

9.05, 5.84–13.98

10.71, 6.04–17.58

–

 Average, Std

11.30, 8.85

15.85, 20.19

–

BMI at diagnosis (kg/m2)

  

0

 Median, IQR

26.22, 23.33–29.35

24.61, 22.60–27.23

–

 Average, Std

26.63, 5.31

25.01, 13.98

–

Onset form

  

5.5 × 10−11

 Spinal

1919, 49.5%

652, 66.3%

–

 Bulbar

562, 14.5%

257, 26.1%

–

 Generalized

11, 0.3%

13, 1.3%

–

 Other

355, 9.1%

61, 6.2%

–

C9orf72

   

 Yes

–

41, 4.2%

–

 No

–

454, 46.2%

–

UMNvsLMN

   

 UMN

–

166, 16.9%

–

 LMN

–

404, 41.1%

–

 Both

–

16, 1.6%

–

  1. Characterization of the population in the PRO-ACT dataset and the Lisbon ALS Clinic dataset. Numerical features are described using Median, Interquartile Range (IQR), Average, and Standard deviation (Std); categorical features are described using the number of patients, and percentage. Mann-Whitney U two-sided test and χ2 two-sided test were used to assess the similarity of the distributions of the continuous and categorical variables, respectively, between the two datasets. Note that some features have missing values and some features are not present in PRO-ACT.
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