Table 3 Disease onset and 1st visit characterization

From: Temporal stratification of amyotrophic lateral sclerosis patients using disease progression patterns

Feature

Overall

Cluster SP

Cluster MPb

Cluster MPs

Cluster FP

p-value

 

N = 983

N = 380

N = 337

N = 199

N = 67

 

Male

545

244

162

119

20

2.2 × 10−8

55.4%

64.2%

48.1%

59.8%

29.9%

 

Age at onset (years)

61.44

58.92

64.50

60.04

69.73

6.8 × 10−13

[60.62; 62.17]

[57.37; 60.47]

[62.99; 66.02]

[57.65; 62.42]

[66.52; 72.94]

SP = MPs

Diagnostic delay (months)

15.85

17.35

13.17

16.96

17.53

0.006

[14.59; 17.12]

[15.45; 19.25]

[11.46; 14.88]

[13.52; 20.40]

[10.34; 24.73]

SP ≠ MPb

BMI

25.01

25.18

25.03

25.09

24.62

0.325

[24.77; 25.26]

[24.77; 25.56]

[24.50; 25.56]

[24.32; 25.87]

[23.62; 25.62]

 

ALSFRS-R at 1st visit

39.83

43.21

40.86

35.46

28.45

0

[39.43; 40.17]

[42.92; 43.50]

[40.47; 41.24]

[34.71; 36.22]

[26.66; 30.23]

SP ≠ MPb ≠ MPs ≠ FP

Slope of ALSFRS-R at 6 months

−1.02

−0.58

−1.16

−1.48

−1.53

0

[-1.09; -0.96]

[-0.65; -0.51]

[-1.26; -1.05]

[-1.66; -1.30]

[-1.82; -1.24]

SP ≠ {MPb, MPs, FP}

VC at 1st visit

86.11

96.94

82.35

79.68

65.92

8.5 × 10−24

[84.29; 87.93]

[94.36; 99.51]

[79.60; 85.19]

[75.74; 83.61]

[59.16; 72.67]

MPb = MPs

Mean phrenic nerve amplitude at 1st visit

0.52

0.67

0.43

0.50

0.42

3.3 × 10−20

[0.50; 0.54]

[0.63; 0.70]

[0.40; 0.46]

[0.45; 0.56]

[0.35; 0.49]

SP ≠ {MPb, MPs, FP}

Mean phrenic nerve latency at 1st visit

8.32

8.21

8.43

8.31

8.24

0.111

[8.21; 8.43]

[8.09; 8.34]

[8.27; 8.59]

[7.97; 8.66]

[7.66; 8.82]

 
  1. Characterization of each cluster (resulted from applying ClusTric to the Lisbon ALS Clinic dataset) according to selected features at disease onset and at 1st visit, and the significance level of each feature. Categorical features (sex) are represented by the number and percentage of patients within the cluster. Continuous features (age at onset, diagnostic delay, BMI, ALSFRS-R at 1st visit, Slope of ALSFRS-R at 6 months, VC at 1st visit, phrenic motor response amplitude and latency at 1st visit) are represented by mean value (first row for each variable) and 95% confidence interval (second row). The statistical tests used for data analysis were the Chi-square two-sided test for categorical features, the non-parametric Kruskal–Wallis two-sided test for non-normal distribution continuous features with the Bonferroni correction, and the One-Way ANOVA for normal distribution features with the Tukey’s Honestly Significant Difference (HSD) test for pairwise comparisons.
  2. SP slow progressors, MPb moderate progressors mainly bulbar, MPs moderate progressors mainly spinal, FP fast progressors.
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