Fig. 3: Fibroin within SpinMed filler facilitates MMRN1 and PECAM1 binding.

a–c Detailed information on MMRN1 binding to fibroin (a), collagen I (b), and PCL (c) at docking sites. Red dashed line: hydrogen bond. d–f Detailed binding sites of PECAM1 docking to fibroin (d), collagen I (e) and PCL (f). Red dashed line: hydrogen bond. g, h Contact area of MMRN1 (g) or PECAM1 (h) with fibroin, collagen I and PCL within 0–100 ns, calculated by molecular dynamics simulation. i, j The number of hydrogen bonds between MMRN1 (i) or PECAM1 (j) and fibroin, collagen I and PCL. PCL polycaprolactone, MMRN1 multimerin 1, PECAM1 platelet endothelial cell adhesion molecule 1. The computational simulations were independently repeated at least three times with similar results.