Fig. 1: Strutural diveristy and biosythesis of glycosphingolipids.

a Representative structure of a glycosphingolipid and the three building blocks. b A simplified scheme of the biosynthesis of mammalian glycosphingolipids. SCD1 Stearoyl-CoA Desaturase-1, FA2H fatty acid 2-hydroxylase, FADS3 fatty acid desaturase 3, DEGS1-2 dihydroceramide desaturase 1 and 2, UDP glycosyltransferase.