Fig. 1: Example rules and corresponding evidence chains generated from Healx KG.

a An example path from the graph satisfying the rule (Compound – binds −> Gene <− activates – Compound – in trial for −> Disease) for a given candidate drug prediction “Lumacaftor” in cystic fibrosis. b Example rules learnt by the model and paths generated for each rule. c Example of an uninformative evidence chain containing two ancestor relationships. Yellow symbol indicates the type compound, white indicates disease, green indicates gene, red indicates phenotype and blue indicates pathway.