Table 2 Genes and pathways found in evidence chains that have an effect in preclinical experiments in the Fmr1 KO mouse model for Sulindac

From: An experimentally validated approach to automated biological evidence generation in drug discovery using knowledge graphs

Gene

P value

Pathway associated

FDR-adjusted pathway P value

PTGS1

0.0269 ↓

Serotonergic synapse

Not significant

MAPK3

0.0028 ↓

Pathways of neurodegeneration

4.55 E-24 ↓(Most significant “Alzheimer’s disease”)

PTGS2

0.0042 ↓

Alzheimer disease

4.55 E-24 ↓

  1. Columns are Gene; HGNC gene symbol, P value; statistical significance of the gene being differentially expressed based on an estimate of log fold change following drug treatment. Values computed by DESeq2, P values are two-sided. Pathway associated; pathway term describing gene function following analysis by gene set enrichment analysis, FDR-adjusted pathway P value; statistical significance of pathway enrichment score corrected for multiple hypothesis testing using Benjamini–Hochberg procedure.
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