Fig. 4: Multivariate analysis results.

Forest plot depicting the logistic regression multivariate analysis for the appearance of NeoRAS WT mCRC in Group A (4a) and Group B (4b). The adjusted odds ratio (OR: blue plot) and 95% confidence interval (CI: black horizontal lines) are shown for each factor. Various clinical factors and their association with the appearance of NeoRAS WT mCRC, as indicated by OR, are analyzed across the cohort using the two-sided Wald chi-squared test. The unadjusted OR of the appearance of NeoRAS WT mCRC is calculated as X/Y. For instance, about liver metastasis, X is defined as “the proportion of mCRC with liver metastases that became NeoRAS WT mCRC,” and Y is defined as “the proportion of mCRC without liver metastases that became NeoRAS WT mCRC.” An adjusted OR is an OR that has been adjusted to account for other predictor variables in the model (adjusted OR: 0.18, 95% CI: 0.09–0.34, P = 1.43 × 10⁻⁷). Vertical dotted line: the null hypothesis. Number of events: Group A = 91; Group B = 42. Source data are provided as a Source Data file. mCRC metastatic colorectal cancer, WT wild-type, RAS rat sarcoma viral oncogene homolog, VEGF vascular endothelial growth factor.