Fig. 7: EGC-1 and ELLI-1 coordinate the production of a subset of Mutator foci-derived siRNAs to regulate gene expression.
From: Germ granule compartments coordinate specialized small RNA production
a Metaprofile analysis showing the distribution of normalized 22G RNA (sRNA-seq) reads (RPM) along 199 genes with upregulated siRNAs in egc-1 or elli-1 animals. b Normalized 22G RNA read distribution across T03D3.5, T16G12.4, sid-1 and rde-11 in the indicated animals. c Proportional Venn diagram showing the overlap among M-class genes and 199 genes with upregulated siRNAs in egc-1 or elli-1 mutants. d Metaprofile analysis showing the distribution of normalized 22G RNA (sRNA-seq) reads (RPM) along 199 genes with upregulated siRNAs in egc-1 or elli-1 mutants in the indicated animals. e Volcano plot showing the fold-change of mRNAs (x-axis) versus the fold-change of siRNAs (Y-axis) of the above 199 genes. sid-1 and rde-11 are indicated. f Normalized mRNA read distribution across sid-1 and rde-11 in the indicated animals.
