Table 1 Astrocytic expression of P2ry1/P2RY1 and Igfbp2/IGFBP2 in neurological disease models in publicly available datasets

GEO accession	Organism	Disease model	Experiment type	Comparison	Gene expression
					P2ry1/P2RY1		Igfbp2/IGFBP2
					Log2FoldChange	FDR	Log2FoldChange	FDR
GSE183050	Mus muscles	Alzheimer’s disease model	RNA-seq	APPPS1::APOE4fl/fl::ALDH1L1-CreERT vs APPPS1::APOE4fl/fl	−0.28	0.99	−0.47	0.96
GSE183050	Mus muscles	Alzheimer’s disease model	RNA-seq	APOE4fl/fl::ALDH1L1-CreERT vs APPPS1::APOE4fl/fl::ALDH1L1-CreERT	0.47	0.95	0.80	0.90
GSE129797	Mus muscles	Alzheimer’s disease model	RNA-seq	WT vs Tau-P301S	−0.30	0.76	−2.4	0.18
GSE138695	Homo sapience	Alzheimer’s disease	RNA-seq	Ctrl vs AD4	0.70	2 × 10⁻⁶	0.19	0.063
GSE138695	Homo sapience	Alzheimer’s disease	RNA-seq	Ctrl vs AD5	1.13	1 × 10⁻¹⁴	0.13	0.22
GSE191131	Mus muscles	Parkinson’s disease model	RNA-seq	WT vs parkinsonian	0.29	0.97	−0.085	0.98
GSE103782	Mus muscles	Stroke model	RNA-seq	Ctrl vs MCAO	0.72	0.59	−0.77	0.46

Astrocyte-specific gene expression in several disease models from Publicly available datasets was analyzed with iDEP.96 and/or OlvTools.

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