Table 1 Circulating levels of cytokines, chemokines, and growth factors after prolonged fluoxetine treatment at steady state
From: Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice
Cytokines levels | Control (n = 9) | Fluoxetine (n = 9) | ||
|---|---|---|---|---|
(pg/ml) | Mean ± SEM | Mean ± SEM | % of change | p |
IL-1α | 41 ± 8 | 35 ± 14 | −15% | NS |
IL-1β | 220 ± 66 | 217 ± 92 | −1% | NS |
IL-2 | 0 ± 0 | 0 ± 0 | – | – |
IL-3 | 23 ± 5 | 30 ± 14 | 32% | NS |
IL-4 | 0 ± 0 | 0 ± 0 | – | – |
IL-5 | 0 ± 0 | 0 ± 0 | – | – |
IL-6 | 0 ± 0 | 0 ± 0 | – | – |
IL-9 | 0 ± 0 | 0 ± 0 | – | – |
IL-10 | 29 ± 8 | 33 ± 13 | 13% | NS |
IL-12(p40) | 97 ± 18 | 126 ± 21 | 29% | 0.019 |
IL-12(p70) | 479 ± 140 | 469 ± 253 | −2% | NS |
IL-13 | 400 ± 111 | 622 ± 166 | 55% | 0.012 |
IL-17 | 0 ± 0 | 0 ± 0 | – | – |
Eotaxin | 865 ± 220 | 1131 ± 490 | 30% | NS |
G-CSF | 59 ± 20 | 57 ± 24 | −4% | NS |
GM-CSF | 145 ± 45 | 152 ± 30 | 4% | NS |
IFN-γ | 13 ± 2 | 14 ± 3 | 11% | NS |
KC | 0 ± 0 | 0 ± 0 | – | – |
MCP-1 | 0 ± 0 | 0 ± 0 | – | – |
MIP-1a | 80 ± 21 | 90 ± 21 | 12% | NS |
MIP-1b | 19 ± 5 | 21 ± 9 | 6% | NS |
RANTES | 37 ± 14 | 26 ± 15 | −27% | NS |
TNF-α | 1983 ± 578 | 2095 ± 736 | 6% | NS |
FGF-b | 70 ± 47 | 438 ± 123 | 421% | 0.0087 |
MIG | 368 ± 151 | 400 ± 154 | 8% | NS |
PDGF-β | 1503 ± 975 | 1304 ± 1069 | −13% | NS |
VEGF | 16 ± 2 | 17 ± 8 | 8% | NS |
