Fig. 3: Rnase4 deficiency exacerbates mouse colitis. | Nature Communications

Fig. 3: Rnase4 deficiency exacerbates mouse colitis.

From: Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis

Fig. 3: Rnase4 deficiency exacerbates mouse colitis.

a, b Body weight loss (a) and disease activity index (b) of WT and Rnase4−/− mice during 2.5% DSS treatment (n = 6). c–f Colon length (c), serum fluorescein isothiocyanate-dextran level (d), representative H&E staining image (e) and histological score of colonic sections (f) from WT and Rnase4−/− mice 8 days after 2.5% DSS administration (n = 6). g, h Quantitative mRNA expression (g) and protein level (h) of indicated cytokines in the colons of WT and Rnase4−/− mice 8 days after 2.5% DSS treatment (n = 6). Scale bar, 50 μm in H&E staining. Data are presented as mean ± SEM for (a–d, f and h) and as mean for (g); * p < 0.05; ** p < 0.01; *** p < 0.001 by two-tailed unpaired Student’s t-test (a–d and h) or two-tailed Mann–Whitney U test (f).

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