Fig. 4: NF1, TSC1, and TβRII were decreased in metastasis nodules in TNBC mouse models. | Nature Communications

Fig. 4: NF1, TSC1, and TβRII were decreased in metastasis nodules in TNBC mouse models.

From: Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression

Fig. 4: NF1, TSC1, and TβRII were decreased in metastasis nodules in TNBC mouse models.The alternative text for this image may have been generated using AI.

A, B Western blot of the protein extractions from mouse primary tumor and lung metastasis in 4T1 and EMT6 syngeneic orthotopic mouse models. The Western blots were repeated for both models with additional samples and showed similar results. C Immunofluorescence staining of NF1, TSC1, and TβRII in the primary tumor and lung metastasis collected at 5 weeks after 4T1 tumor cell injection. Representative images are shown. Quantitative data on fluorescence intensity are on the right. Statistical significance was determined by two-tailed Student’s t-test for (C). All graphs show mean ± s.d.

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