Fig. 6: Identifying key TF regulatory networks driving OIS.
From: Single-cell total-RNA profiling unveils regulatory hubs of transcription factors
a Heatmap of the activities of the verified TFs. b Establish the regulatory links between the TFs within TF Hub 3.1 by correlating the changes in the unspliced RNA of the TF of interest with the changes in the spliced RNA of the other TFs. The direct regulatory links (colored in red) were identified by ChIP-seq verification. The corresponding ChIP-seq peaks were plotted on the right. c The TF regulatory network of TF Hub 3.1. The regulatory network was established based on the direct regulatory links between different TFs. The TFs belonging to TF Hub 2 are colored in yellow. d Establish the regulatory links between the TFs within TF Hub 3.2 by correlating the changes in the unspliced RNA of the TF of interest with the changes in the spliced RNA of the other TFs. The direct regulatory links (colored in red) were identified by ChIP-seq verification. The corresponding ChIP-seq peaks were plotted on the right. e The TF regulatory network of TF Hub 3.2. The regulatory network was established based on the direct regulatory links between different TFs.
