Fig. 4: Simulation results with real LD patterns derived from UK Biobank data.
From: A robust cis-Mendelian randomization method with application to drug target discovery
Top: Scenario 1 with SNPs in \({{{{{{{\mathcal{I}}}}}}}}_{X}\) and \({{{{{{{\mathcal{I}}}}}}}}_{Y}\), and corresponding genetic effect sizes specified according to real data. Bottom: Scenario 2 with SNPs in \({{{{{{{\mathcal{I}}}}}}}}_{X}\) and \({{{{{{{\mathcal{I}}}}}}}}_{Y}\), and corresponding genetic effect sizes randomly generated. From left to right are empirical type-I error under the null, power under the alternative, and root mean squared error (RMSE) under the null. Colors represent different methods being compared. Source data are provided as a Source Data file.
