Fig. 4: The cryo-EM structure of DSR2-DSAD1 complex.
From: The structural basis of the activation and inhibition of DSR2 NADase by phage proteins
a, b Cryo-EM density maps of DSR2-DSAD1 complex with DSAD1 on the same side (a) or opposite sides (b). The Sir2 tetramer is colored in cyan, while the helical region in the DSR2 dimer is colored in forest green and magenta, and the DSAD1 is colored in orange. c, d Ribbon diagram of the structures of DSR2 bound with two DSAD1 molecules on the same side (c) or opposite sides (d). The domains are colored as above. e Electron density of the DSAD1 docked with the structural model. f Ribbon diagram of the DSAD1. g Closed-up views of DSR2 opened cavity bound with DSAD1, closed cavity and superimposed structures of closed cavity to the DSAD1 bound cavity.
