Fig. 2: Antimicrobial activity of F8 in vivo.
From: A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance
a–d Bacterial load in the blood, liver, spleen, and kidney in the different treatment groups in a mouse S. aureus bacteraemia model (n = 6). Statistics: two tailed t test. Mean with SD. a (P < 0.0001 (FLO-PBS), P < 0.0001 (F8-PBS), P = 0.0332 (F8-FLO)). b (P < 0.0001 (FLO-PBS), P < 0.0001 (F8-PBS), P = 0.0727 (F8-FLO)). c (P < 0.0001 (FLO-PBS), P < 0.0001 (F8-PBS), P = 0.0084 (F8-FLO)). d (P < 0.0001 (FLO-PBS), P < 0.0001 (F8-PBS), P = 0.0217 (F8-FLO)). ns, not significant, *P < 0.05, **P < 0.01, ***P < 0.001. e Histopathological assessment of the liver, spleen, and kidney in the different treatment groups in a mouse S. aureus bacteraemia model. Scale bar, 100 μm. Source data are provided as a Source Data file.
