Table 1 MIC of broad-spectrum antibacterial small molecule compounds based on SBDD and modular synthesis

From: A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance

Organism

MIC (µM)

 

FLO

F1

F2

F3

F4

F6

F7

F8

F11

F13

F14

F15

 E. coli

8

16

32

>128

>128

16

16

8

>128

>128

16

>128

 S. typhi

4

16

32

>128

>128

8

16

2

>128

>128

8

>128

P. aeruginosa

>128

>128

>128

>128

>128

128

>128

128

>128

>128

>128

>128

 S. aureus

16

32

64

>128

>128

16

32

8

>128

>128

16

>128

 B. subtilis

4

16

16

>128

128

4

4

2

>128

>128

4

>128

 E. faecalis

16

16

32

>128

128

8

8

4

>128

>128

8

>128

 P. multocida

8

16

8

>128

64

4

4

2

>128

>128

2

>128

 A. pleuropneumoniae

8

32

32

>128

128

4

16

4

>128

>128

8

>128

 S. suis

16

64

64

>128

>128

16

16

8

>128

>128

32

>128

 H. parasuis

32

64

64

>128

>128

16

32

8

>128

>128

16

>128

  1. MIC Minimum Inhibitory Concentration, FLO florfenicol.
  2. The MICs of antibiotics were determined by the broth microdilution method (see “Methods”) following the Clinical and Laboratory Standards Institute (CLSI) guidelines. The assay was done three times to confirm results (n  =  3). Source data are provided as a Source Data file.
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