Table 2 MIC of F8 against antibiotic-resistant strains

From: A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance

Organism

MIC (µM)

 

F8

FLO

 Methicillin-resistant S. aureus B1-1

8

32

Polymyxin B-resistant E. hormaechei wb 4

16

128

 Florfenicol-resistant S. suis 1136

8

64

 Florfenicol-resistant S. suis 1194

4

16

 Florfenicol-resistant S. suis 1197

8

32

 Florfenicol-resistant S. suis 1655

8

32

 Florfenicol-resistant S. suis 1658

4

32

 Florfenicol-resistant S. suis 1669

16

64

Florfenicol-resistant H. parasuis 1565

8

32

Florfenicol-resistant H. parasuis 1614

4

16

Florfenicol-resistant H. parasuis 1651

8

32

 Ampicillin-resistant S. typhi BYG 9

4

64

Sulfamethoxazole-resistant S. typhi BYG 21

4

32

 Doxycycline-resistant S. typhi BYG 11

4

32

 Doxycycline-resistant S. typhi BYG 25

8

32

 Doxycycline-resistant S. typhi BYG 31

8

32

  1. MIC Minimum Inhibitory Concentration, FLO florfenicol.
  2. The MICs of antibiotics were determined by the broth microdilution method (see “Methods”) following the Clinical and Laboratory Standards Institute (CLSI) guidelines. The assay was done three times to confirm results (n  =  3). Source data are provided as a Source Data file.
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