Fig. 3: In vitro rat plasma stability of selected insulin analogues.
From: Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec
The disappearance of intact insulin analogues upon incubation in rat plasma (a), with the corresponding appearance of insulin B-chains (b), n = 2. All insulin B-chains contain an internal disulphide bond connecting Cys 7 with Cys 19, assessed by the exact monoisotopic masses. See text for definition of insulin substitutions. Source data are provided as a Source Data file.
