Fig. 2: Pseudotime transitions across TIMs. | Nature Communications

Fig. 2: Pseudotime transitions across TIMs.

From: A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint blockade

Fig. 2

a Average pseudotime of each cell type in the treatment groupsand the response groups. b Violin plots showing the distribution of Pseudotime ordering for responders and non-responders in each cell type. Data are presented as mean values ± SEM (Standard Error of the Mean), indicated by the red dots and associated error bars. The box plots within the violin plots represent the interquartile range (IQR), with the center line indicating the median. The whiskers extend to the minimum and maximum values within 1.5 times the IQR from the 25th and 75th percentiles. Statistical significance was determined using two-sided t-test. Multiple comparison adjustment was carried out using BH FDR. P-values for each comparison between responder and non-responder groups in each cell type are labeled in the plots, shown under the names of the cell types as “P = (p-value)”. c Enriched pathways in each of the pseudotime branches for the three categories of cells, namely Macro/Mono (representing macrophages and monocytes), DC, and Mast. d Normalized enrichment scores (NES) of the enriched hallmark pathways in each pseudotime branch.

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