Fig. 5: Targeted analysis of the highly interacting TIMs. | Nature Communications

Fig. 5: Targeted analysis of the highly interacting TIMs.

From: A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint blockade

Fig. 5

a Standardized expression values of the TF signatures of the nine TIMs in the response groups are shown in the plot. Color gradient indicates the standardized expression values of the TFs. b TFs with common activity patterns across cancer types in the response groups of these cell types. For each cell type and regulon, we performed two-tailed paired t-test to compare the activity scores or the expression values of the regulon between Post(R) and Post(NR) across cancer types. The analysis included five different cancer types, with no technical replicates involved. c Survival analysis based on the expression of the signature genes of these cell types. Log-rank test was used to compare the survival distributions within each survival plot. No multiple testing correction was carried out. d Response index and GSEA index separating the samples of the two response groups. Each point represents a sample in the study with response information. e Multiplex immunofluorescence staining has delineated the spatial relationships between the Macro_FOLR2 + APOE+ cell subpopulation and T cells, as well as their abundance in ICB responders and non-responders among CRC patients.

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