Fig. 3: Time-calibrated phylogeny and gene evolution of Brucella melitensis.
From: An 8000 years old genome reveals the Neolithic origin of the zoonosis Brucella melitensis
a Beast29 phylogeny using a strict molecular clock and Coalescent Bayesian Skyline tree prior. The 95% Highest Posterior Distribution (HPD) are indicated blue, and annotated if mentioned in the text. The B. abortus reference genome was included to estimate the B. melitensis-B. abortus speciation time. Samples were aligned to the B. melitensis reference genome. x-axis is Years Before Present (BP - relative to the year 1950). b Missense and nonsense mutations fixed in B. melitensis today are either early evolving or late evolving, occurring before or after the divergence of the Mentese6 Neolithic genome from the ancestor of modern B. melitensis. Dashed lines indicate the extent of the early or late evolving epochs, based on the 95% HPD of node ages from the Beast phylogeny.
