Fig. 5: Anti-PEG antibody effects on blood circulation and intrahepatic cellular distribution of sLip/Dox.
From: Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin
a Plasma pharmacokinetics (PK) profiles of Dox in normal and pre-stimulated mice. Dox distribution in KC (b), LSEC (c), and zonated HC (d–f) was evaluated. Compared to normal mice, stimulated mice were injected with sLip at a dose of 5 mg/kg HSPC 5 days before being treated by sLip/Dox. Both the normal and pre-stimulated mice were intravenously injected with sLip/Dox at a dose of 5 mg/kg Dox. The statistical significance was analyzed by two-way ANOVA multiple comparisons corrected by Sidak’s test except for (a) (two-tailed unpaired t-test). Data were means ± SDs for a–f (n = 3 mice). Source data are provided as a Source Data file.
