Fig. 7: MyoAAV-delivered FL-dystrophin restored the membrane localization of cavin-4 and its associated ERK signaling in the heart muscles of mdx^4cv mice.

All animal experiments were performed in WT and mdx^4cv male mice with the C57BL/6J genetic background. a Immunofluorescence staining of cavin-4 in heart sections of WT and mdx^4cv mice treated with or without AAV-FL-v2, AAV-µ-v1, or AAV-µ-v2 (n = 3 mice per group). Scale bar: 100 µm. b–d Western blot and quantification of ERK phosphorylation in the heart muscles of WT and mdx^4cv mice treated with or without AAV-FL-v2, AAV-µ-v1, or AAV-µ-v2 (n = 4 mice per group). Data were mean ± SEM. Statistical analyses were performed by one-way ANOVA with Tukey’s multiple comparisons test except otherwise specified. Source data are provided as a Source Data file.