Fig. 7: Partial transient rescue of anemia in Klf1H350R/− mice with L-leucine supplementation. | Nature Communications

Fig. 7: Partial transient rescue of anemia in Klf1H350R/− mice with L-leucine supplementation.

From: Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis

Fig. 7

Hemoglobin (Hb) levels and RBC counts (RCC) in mice at baseline and every second week following supplementation with L-leucine (1.5% weight/vol) in the drinking water for Klf1+/− (red; n = 8) and Klf1H350R/− (blue; n = 9) mice. There is no significant change in Hb levels or RCC in Klf1+/− mice, but a significant and variable upregulation of Hb and RCC in Klf1H350R/− mice at 4 weeks (**p < 0.005) and at 6 weeks (*p < 0.01) after L-leucine supplementation. Two-way ANOVA with a Tukey post-hoc test was used for statistical analysis.

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