Fig. 1: Design peroxidase mimics with synergetic effect of redox-active vanadium and Lewis acidic alkali earth metal. | Nature Communications

Fig. 1: Design peroxidase mimics with synergetic effect of redox-active vanadium and Lewis acidic alkali earth metal.

From: Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme

Fig. 1: Design peroxidase mimics with synergetic effect of redox-active vanadium and Lewis acidic alkali earth metal.

a Schematic illustration of the active site of natural horseradish peroxidase C1A (HRP C1A), in which Fe3+ is located in protoporphyrin IX as redox site in coordination with the proximal histidine ligand and 2 mol Ca2+ as Lewis acid site at the proximal and distal sites of redox site. The alkaline-earth metal M (M = Mg, Ca, Sr) and the active center V are connected by non-covalent bonds in bioinspired MxV2O5·nH2O, which resemble the Lewis acid site and the redox site in HRP C1A, respectively. b Bioinspired MxV2O5·nH2O serves as the peroxidase mimics against bacteria for accelerating infected wound healing.

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