Fig. 2: Ablating adult neurogenesis decreases spatial information content at the single cell level.
From: Adult neurogenesis improves spatial information encoding in the mouse hippocampus
a–d Population Fisher information determined with noise correlations and after random shuffling to disrupt noise correlations (RC vs RC w/o NC: p = 0.057 n.s, n = 5 mice per group, EE vs EE w/o NC: p = 0.15 n.s, n = 5 mice per group, Irr+RC vs Irr+RC w/o NC: p = 0.20 n.s., n = 4 mice per group, Irr+EE vs Irr+EE w/o NC: p = 0.014, n = 4 mice per group, Mann-Whitney U test). e Single-cell spatial information content determined using Fisher information (FI) (RC vs Irr+RC: ****p < 1/100000, nRC = 5 mice, 277 neurons, nIrr+RC = 4 mice, 253 neurons, EE vs Irr+EE: ****p < 1/100000, nEE = 5 mice, 201 neurons, nIrr+EE = 4 mice, 412 neurons, statistical analysis: bootstrap (two-sided) and Bonferroni correction for multiple comparisons (see methods). Error bars are mean ± SEM. f Distribution of spatial information content across the imaged neurons. g Distance between two positions that DG single-cells are able, on average, to discriminate correctly 70% of the time (RC vs Irr+RC: **p = 0.0038 nRC = 5 mice, nIrr+RC = 4 mice, EE vs Irr+EE: **p = 0.0012, nEE = 5 mice, nIrr+EE = 4 mice, statistical analysis: ANOVA, Holm-Sidak correction for multiple comparisons). Error bars represent +/- SEM in all plots.
