Table 1 Genome-wide significant loci from GWAS performed on the PD cohorts in UKB EUR^*

SNP-effect allele	Closest Gene	MAF^a	Beta	P	Effect	V2G^b	CADD^c	RDB^d	ClinVar^e
rs35749011-A	KRTCAP2	0.015	0.55	2.3E-8	intergenic	0.15	0.64	5	NA
rs34637584-A	LRRK2	0.002	2.27	7.9E-9	missense	0.3	28.2	3a	Pathogenic
rs1474055-T	STK39	0.12	0.26	1.6E-10	intergenic	0.25	1	7	NA
rs356203-T	SNCA	0.63	−0.18	5.4E-11	intronic	0.21	6.6	7	NA
rs7155501-G	GCH1	0.44	−0.15	1.8E-8	intronic	0.16	4.4	4	NA
rs56214516-C	CRHR1	0.2	−0.26	8E-13	intronic	0.23	5.7	5	NA
rs429358-C	APOE	0.14	0.22	2.5E-9	missense	0.4	16.65	4	Pathogenic/likely pathogenic

^aMAF: Minimum allele frequency.
^bV2G score extracted from OpenTargets⁹⁸, which represents a quantile rank for a given SNP, relative to all other SNPs, mapping to a gene based on the following evidence: in silico functional prediction from VEP, eQTL, pQTL, PC Hi-C, Enhancer-TSS correlation, DHS-promoter correlation, Canonical TSS.
^cCombined Annotation Dependent Depletion (CADD⁹⁹) score >10 corresponds to the top 10% most deleterious alterations in the genome; CADD > 20 to the top 1% and CADD > 30 to the top 0.1%.
^dRegulomeDB (RDB¹⁰⁰) scores:1a-1f = likely to affect binding and linked to expression of a gene target; 2a–2c = likely to affect binding; 3a–3b = less likely to affect binding; 4–7 = minimal binding evidence.
^eLandrum et al.¹⁰¹.
^*The top SNP in each locus is reported.

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