Table 2 Genome-wide significant loci from the meta-analysis of the UKB and FinnGen PD cohortsa
SNP-effect allele | Closest Gene | MAF-FinnGen | Beta | P | Effect | FM-PPb | V2G | CADD | RDB | ClinVar |
|---|---|---|---|---|---|---|---|---|---|---|
rs2230288-T | GBA | 0.04 | 0.4 | 9.7E-19 | missense | 0.9 | 0.26 | 16.14 | 1 f | NA |
rs9917256-A | STK39 | 0.16 | 0.15 | 8E-11 | intergenic | 0.85 | 0.19 | 0.37 | 7 | NA |
rs34311866-C | TMEM175 | 0.2 | 0.17 | 1.25E-12 | missense | 1 | 0.36 | 12.9 | 4 | NA |
rs1372519-G | SNCA | 0.8 | 0.18 | 3E-12 | 5‘ UTR variant | 0.9 | 0.36 | 4 | 4 | NA |
rs2760980-A | HLA-DRB1 | 0.15 | −0.15 | 2.8E-9 | intergenic | 0.6 | NA | 7.2 | 7 | NA |
rs34637584-A | LRRK2 | 0.002 | 2.27 | 7.16E-12 | missense | 0.9 | 0.3 | 28.2 | 3a | Pathogenic |
rs10847839-C | HIP1R | 0.34 | −0.14 | 4.7E-8 | intronic | 1 | 0.11 | 1.6 | 2b | NA |
rs11158026-T | GCH1 | 0.4 | −0.1 | 3.4E-8 | intronic | 0.95 | 0.21 | 1.2 | 1d | NA |
rs4630591-T | KANSL1 | 0.8 | −0.25 | 1.4E-18 | intronic | 0.9 | 0.45 | 1.1 | 1 f | NA |
rs6857-T | NECTIN2 | 0.19 | 0.13 | 1.7E-9 | 3‘ UTR variant | 0.75 | 0.17 | 2 | 5 | NA |
