Fig. 5: Significant gene–environment interaction effects of the lead QR variants for 39 traits.
From: Genome-wide discovery for biomarkers using quantile regression at biobank scale
a The heatmap shows \(-{\log }_{10}(p\,\text{-value}\,)\) of gene-environment interaction tests for the lead QR association at the loci detected by QR. * denotes nominally significant GxE interaction effects (p-value < 0.05) and ** denotes significant effects after Bonferroni correction (p < 0.05/(5 ⋅ 7, 297) = 1.37e − 06). Sample size by trait can be found in Table S4. b The empirical distribution of the number of significant gene-environment interactions when variants are chosen randomly among significant variants identified by LR or QR.
