Fig. 6: Association of rs1354034 at the ARHGEF3 locus with Platelet distribution width.
From: Genome-wide discovery for biomarkers using quantile regression at biobank scale
a \(-{\log }_{10}(p\,\text{-value}\,)\) of QR with the lead QR SNP per locus shown as diamond. b \(-{\log }_{10}(p\,\text{-value}\,)\) of LR with the lead QR SNP per locus shown as diamond. Colors indicate the LD (r2) to the lead SNP for each variant. c The estimated quantile specific effects (dots) and the SE (error bars) are shown at τ = 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9. d The curves are the τ = 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 empirical conditional quantile functions. Shown in black is also the LR line fitted to the data. e gene-environment interaction between rs1354034 and age. The statistics in a-e were derived from n = 316,707 individuals used in the platelet distribution width GWAS. Statistical significance was determined by QR rank score test in panels a-d and two-sided t-test in panel e.
