Fig. 3: Histotype-specific proteins and their functions in the PDS-EOC cohort.

A The heatmap visualizes the expression of 606 histotype-specific proteins among normal and five histotypes of primary EOCs. Five clusters of histotype-specific DEPs were highlighted in blue or red frame to label its dysregulation. Top two enriched pathways by Metascape were labeled by connecting lines with corresponding proteins. Outliers of z scores of protein expression were defined according to Tukey’s fences where k equals 2. NA represents not available. B Differential expression of proteins involved in angiogenesis between normal (n = 31) and CCOC (n = 40) group by two-sided unpaired Welch’s t test. The box in each group is constructed from the first to the third quartile, with a horizontal line indicating the median value. The whiskers extend from the box to represent the range of data within 1.5 times the interquartile range. C Protein expression among normal group (n = 31) and five histotypes from PDS-EOC cohort (485 samples in HGSOC group, 18 samples in LGSOC group, 40 samples in CCOC group, 15 samples in MCOC group and 43 samples in EMOC group) by two-sided unpaired Welch’s t test. The box in each group is constructed from the first to the third quartile, with a horizontal line indicating the median value. The whiskers extend from the box to represent the range of data within 1.5 times the interquartile range. Source data are provided as a Source Data file.