Fig. 7: Exogenous Tregs primarily exert their therapeutic effect through IL-10. | Nature Communications

Fig. 7: Exogenous Tregs primarily exert their therapeutic effect through IL-10.

From: Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice

Fig. 7

a–e Mice received saline or Tregs from Il10 knockout mice (TregsII10−/−) 1 day post-MI. The experimental design is shown in (a). b Representative parasternal long-axis views of the left ventricle. The red trace is end-diastolic, and the green is end-systolic. Scale bar: 2 mm. c Left ventricular ejection fraction measured by echocardiography 7 and 28 days post-MI (n = 7). d Representative histology of whole transverse heart sections from apex to base stained with Masson’s Trichrome staining, 28 days post-MI. Scale bar: 2 mm. e Quantification of fibrosis by histology expressed as percentage of the left ventricle (n = 7). For all graphs, boxes show median (centre line) and interquartile range (edges), whiskers show the range of values and dots represent individual data points. Two-way ANOVA with Bonferroni post-hoc test for pair-wise comparisons was used to compare the groups in (c). Two-tailed Student’s t-test was used to compare the groups in (e). P-values are indicated, n.s. indicates non-significant. Panel (a) created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license (https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en).

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