Table 2 Cox proportional hazards models showing EFS risk factors in MER

From: Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation

 

Univariate (Feature)

Bi-variate (A7 + Feature)

  

A7

Feature

Feature

HR

p

HR

p

HR

p

A7

2

0.006

–

–

–

–

Age > 65

1.2

0.32

1.98

0.007

1.19

0.36

LDH > ULN

2.2

0.0001

1.73

0.04

2.1

0.0003

IPI > 2

2.5

4.24E-06

1.73

0.04

2.44

7.90E-06

ECOG > 1

2.13

5.00E-04

1.81

0.02

2.07

8.00E-04

Ann Arbor Stage >2

1.97

6.00E-04

1.88

0.01

1.92

1.00E-03

Bulky Disease

1.35

0.31

2.06

0.004

1.44

0.22

Extranodal sites > 1

1.53

0.06

2.05

0.005

1.56

0.04

Double-hit FISH

2.03

0.03

2.63

0.0007

2.33

0.01

ABC COO

1.3

0.16

1.91

0.02

1.12

0.58

  1. Each row represents a clinical feature, from which two models are built—the univariate model uses only the feature in question, while the multivariate version models EFS as a function of the feature plus A7 status. Reported are the hazard ratios and p-values observed for each feature in both the univariate and multivariate models. A7 remains significantly prognostic even when accounting for other clinical features.
Back to article page